Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

Free intracellular calcium ([Ca2+]i), in addition to being an important second messenger, is a key regulator of many cellular processes including cell membrane potential, proliferation, and apoptosis. In many cases, the mobilization of [Ca2+]i is controlled by intracellular store activation and calcium influx. We have investigated the effect of several ion channel modulators, which have been us...

متن کامل

A simulation study of calcium release channel

The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The d...

متن کامل

Calcium-induced calcium release

How are calcium levels increased within cells? Increases in intracellular calcium arise through either calcium influx across the plasma membrane or release from intracellular calcium stores, which is usually either the endoplasmic reticulum (ER) or, in muscle, the sarcoplasmic reticulum (SR). Release of calcium from the ER/SR is activated by a variety of second messengers, such as inositol 1,4,...

متن کامل

A calcium-induced calcium release mechanism mediated by calsequestrin.

Calcium (Ca(2+))-induced Ca(2+) release (CICR) is widely accepted as the principal mechanism linking electrical excitation and mechanical contraction in cardiac cells. The CICR mechanism has been understood mainly based on binding of cytosolic Ca(2+) with ryanodine receptors (RyRs) and inducing Ca(2+) release from the sarcoplasmic reticulum (SR). However, recent experiments suggest that SR lume...

متن کامل

Calcium-induced calcium release mechanism in guinea pig taenia caeci

Fura-2 was used to measure the amount of Ca released from the intracellular Ca store of a saponin-skinned smooth muscle fiber bundle of the guinea pig taenia caeci (width, 150-250 microns) placed in a capillary cuvette at 20-22 degrees C. The amount of Ca actively loaded into the store was assayed when released by the application of 50 mM caffeine and/or 10 microM inositol 1,4,5-trisphosphate (...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics

سال: 2016

ISSN: 0022-3565,1521-0103

DOI: 10.1124/jpet.116.236695